gallbladder, pancreas and stomach

Most people with gallstones never have a serious complication. However, gallstones can sometimes cause complications, such as:

  • inflammation of the gallbladder (cholecystitis);
  • inflammation of the bile duct (cholangitis);
  • inflammation of the pancreas (biliary pancreatitis); and
  • obstruction of the intestine (gallstone ileus).


Cholecystitis (inflammation of the gallbladder) is usually the result of a gallstone lodging in the neck of the gallbladder or the cystic duct (one of the bile ducts). It may be triggered by a large meal or a meal with fatty foods.


Symptoms include:

  • sudden, severe pain in the upper abdomen that lasts more than 12 hours;
  • tenderness when the abdomen is touched;
  • nausea and vomiting; and
  • fever.

Acute cholecystitis is distinguished from biliary colic, which is the pain caused when gallstones temporarily obstruct a bile duct, but no gallbladder inflammation is present. Biliary colic pain tends to be less sharp, there is no fever, and the abdomen is less exquisitely tender.


Acute cholecytitis treatment consists of:

  • pain relievers, usually given by injection;
  • antibiotics (the inflammation is not always due to infection, but if secondary infection is present, you may need antibiotics);
  • fluids, which are usually given through a drip into a vein.

It is usual for the gallbladder to be removed in order to avoid further pain and complications.


Cholangitis (inflammation of the bile ducts) may occur if your bile ducts become blocked and subsequently infected with bacteria from the small intestine. This is a serious condition requiring urgent treatment.


Symptoms of acute cholangitis include:

  • fever;
  • abdominal pain; and
  • jaundice (a yellow discolouration of the skin and whites of the eyes).


Acute cholangitis is treated with:

  • antibiotics; and
  • a procedure known as endoscopic retrograde cholangiopancreatography (ERCP) to unblock the bile ducts by removing the gallstones.

Gallstones that block the bile ducts and cause jaundice without inflammation also need to be removed.

Acute biliary pancreatitis

Pancreatitis (inflammation of the pancreas) is a potentially serious disorder that occasionally develops in people with gallstones. It is more common in people with numerous small stones, and occurs when gallstones obstruct the duct leading from the pancreas (pancreatic duct).


Pancreatitis symptoms include:

  • severe upper abdominal pain that may feel like it goes through to your back;
  • nausea and vomiting; and
  • fever.


Acute pancreatitis requires urgent hospitalisation.

In addition to supportive care, pancreatitis caused by gallstones is treated by removing the gallstones via either:

  • surgery to remove the gallbladder and gallstones; or
  • a procedure known as endoscopic retrograde cholangiopancreatography (ERCP) and sphincterotomy. ERCP involves visualising blockages in the bile ducts and removing the gallstones that are causing the blockage.

Gallstone ileus

Gallstone ileus is a condition where gallstones obstruct the small or large intestine. Gallstone ileus can happen when an inflamed gallbladder becomes stuck to the intestine, and the gallstones erode their way through the gallbladder wall and into the intestine where they cause a blockage.


Symptoms of gallstone ileus include:

  • abdominal pain;
  • abdominal bloating;
  • nausea and vomiting; and
  • constipation.


The treatment for this is urgent surgery to remove the gallstone and relieve the bowel obstruction.

Gallbladder cancer

Having gallstones can increase the risk of developing gallbladder cancer, but this type of cancer is rare — most people with gallstones never develop gallbladder cancer.

Surgical removal of the gallbladder is usually recommended for people who have had complications resulting from gallstones.

Last Reviewed: 01/09/2015



1. Acute cholecystitis (revised October 2014). In: eTG complete. Melbourne: Therapeutic Guidelines Limited; 2015 Jul. (accessed Aug 2015).
2. Ascending cholangitis (revised October 2014). In: eTG complete. Melbourne: Therapeutic Guidelines Limited; 2015 Jul. (accessed Aug 2015).
3. Acute pancreatitis (revised February 2011; amended October 2014). In: eTG complete. Melbourne: Therapeutic Guidelines Limited; 2015 Jul. (accessed Aug 2015).
4. MayoClinic. Gallstones (updated 25 Jul 2013). (accessed Aug 2015).