(rasagiline mesilate) tablets
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Rasazil. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking Rasazil against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine. You may need to read it again.
What Rasazil is used for
Rasazil is used to treat the symptoms of Parkinson’s disease. It can be taken with or without dopamine agonist or levodopa therapy.
Parkinson’s disease is a condition of the brain that mainly affects body movement. The three main symptoms of Parkinson’s disease are:
- shaking (tremor);
- muscle stiffness; and
- slow and unsteady movement.
In Parkinson’s disease, there is a loss of cells producing dopamine in certain areas in the brain.
Rasazil works by increasing and maintaining the level of dopamine in your brain which will decrease symptoms of Parkinson’s disease.
Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed it for another reason.
This medicine is available only with a doctor’s prescription. It is not addictive.
Rasazil should not be given to children under 18 years of age as there is no specific information about such use. Always ask your doctor before giving medicines to children.
Before you take Rasazil
When you must not take it
Do not take Rasazil if you have ever had an allergic reaction to rasagiline or any of the ingredients listed at the end of this leaflet.
If you have an allergic reaction you may get a skin rash, have difficulty in breathing, get symptoms of hay fever or feel faint.
If you are already taking Rasazil, do not take another medicine called:
- monoamine oxidase inhibitors (MAOI), whether used to treat depression, Parkinson’s disease or any other condition;
- other medicinal and natural products without prescription which have MAOI activity (eg. St John’s Wort);
- pethidine, a strong pain killer;
- ciprofloxacin, an antibiotic used to treat infection.
Wait at least 14 days between stopping Rasazil and starting your MAOI medicine or pethidine.
Do not take Rasazil if you have a problem with your liver.
Do not take Rasazil after the expiry date (EXP) printed on the pack. It may have not work as well.
Do not take Rasazil if the packaging is torn or shows signs of having been tampered with.
If you are not sure whether you should start taking this medicine, talk to your doctor.
Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.
Tell your doctor if you have a problem with your liver.
Tell your doctor if you are pregnant or plan to become pregnant or are breast-feeding. Your doctor can discuss with you the risks and benefits involved.
Tell your doctor if you smoke. Nicotine can affect the amount of rasagiline that is in your body.
Tell your doctor if you notice any unusual skin lumps or moles which are new or have changed.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription, from a pharmacy, supermarket or health food shop.
The following medicines require specific medical advice before being taken together with Rasazil:
- Medicines used to treat depression, anxiety, panic disorder, obsessive-compulsive disorder or pre-menstrual dysphoric disorders. Examples of such medicines include selective serotonin reuptake inhibitors (SSRIs), tricyclic and tetracyclic antidepressants.
- Other medicines used to treat depression called fluoxetine and fluvoxamine.
Wait at least 5 weeks between stopping fluoxetine treatment and starting treatment with Rasazil. Wait 14 days between stopping Rasazil treatment and starting treatment with fluoxetine or fluvoxamine.
- Dextromethorphan, a medicine for cough.
- Substances with sympathomimetic activity such as those present in ‘cold and flu’ oral tablets and nasal drops containing ephedrine or pseudoephedrine.
- Clozapine, a medicine used to treat schizophrenia.
- Other medicines used to treat symptoms of Parkinson’s disease.
Your doctor or pharmacist can tell you what to do if you are taking these or any other medicines.
If you have not told your doctor about any of these things, tell them before you take Rasazil.
How to take Rasazil
Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.
If you do not understand the instructions on the label, ask your doctor or pharmacist for help.
How much to take
Your doctor will tell you how much Rasazil to take each day. Take the amount your doctor tells you to.
The usual dose for Rasazil is one tablet of 1 mg taken orally once a day.
How to take it
Swallow the tablet whole with a full glass of water.
Rasazil can be taken with or without food.
When to take it
Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it.
How long to take it
Do not stop taking this medicine without first checking with your doctor.
If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.
Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.
If you are not sure what to do, ask your doctor or pharmacist.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints.
If you take too much (overdose)
Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26) for advice, or go to the Accident and Emergency department at your nearest hospital if you think that you or anyone else may have taken too much Rasazil. Do this even if there are no signs of discomfort or poisoning. Keep telephone numbers for these places handy.
While you are taking Rasazil
Things you must do
Tell your doctor immediately if you become pregnant while taking Rasazil.
Tell all doctors, dentists and pharmacists who are treating you that you are taking Rasazil, especially if you are being started on any new medicines.
Keep all of your doctor’s appointments so that your progress can be checked.
Things you must not do
Do not take Rasazil to treat any other complaints unless your doctor tells you to.
Do not give your medicine to anyone else, even if their symptoms seem similar to yours.
Do not drive, operate machinery or work at heights during treatment if you have fallen asleep without warning, prior to the use of Rasazil.
Things to be careful of
As with any new medicine, make sure you know how Rasazil affects you before you drive or operate machinery.
Rasazil may cause you to feel sleepy in the daytime during daily activities.
Be careful when drinking alcohol while you are taking this medicine.
If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. Standing up slowly, especially when you get up from a bed or chair, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor.
Scientific evidence suggests that Parkinson’s disease is associated with a higher risk of skin cancer (including melanoma). During the development (placebo-controlled clinical trials), melanoma was observed in both rasagiline- and placebo-treated patients (around 0.5% vs 0.2% respectively). People with Parkinson’s disease, including those taking Rasazil, should undergo periodic examination of the skin.
Eating excessive amounts of foods rich in tyramine (eg. aged cheese, red wine) while you are taking Rasazil could very rarely cause an increase in your blood pressure and should be avoided. If you do eat these foods while you are taking Rasazil and do not feel well, you should contact your treating doctor. Your treating doctor or pharmacist can advise you on what foods are rich in tyramine and what your risk of having a reaction may be.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Rasazil. This medicine helps most people with Parkinson’s disease, but it may have unwanted side effects in some people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by the following lists of side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following side effects and they worry you:
- flu syndrome;
- neck pain;
- joint pain;
- eye inflammation;
- abdominal pain;
- accidental injury (primarily falls);
- dizziness when you stand up due to low blood pressure;
- weight loss;
- difficulty in moving normally;
- obsessive thoughts or impulsive behaviour.
Contact your doctor if you notice any suspicious skin changes because there may be an increased risk of skin cancer (melanoma) with the use of this medicine.
Tell your doctor or pharmacist if you notice anything else that is making you feel unwell. Some people may get other side effects while using Rasazil.
After taking Rasazil
Keep Rasazil in the blister pack until it is time to take them.
Keep Rasazil in a cool dry place where the temperature stays below 25°C.
Do not store Rasazil or any other medicine in the bathroom or near a sink or stove. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.
Keep Rasazil where young children cannot reach it. A locked cupboard at least one-and-a-half metres above ground is a good place to store medicines.
Dispose of the tablets where children cannot reach them.
Ask your pharmacist what to do with any Rasazil you may have left over if your doctor tells you to stop using it, or if you find that the tablets have passed the expiry date.
What it looks like
White to off-white, circular, flat faced, beveled edge, uncoated tablets, debossed with “1” on one side and plain on the other side.
Rasazil is available in blister packs (Aluminium/Aluminium) of 10 and 30 tablets.
Not all pack sizes may be marketed.
Rasazil tablets contain 1 mg of rasagiline (as rasagiline mesilate).
- Microcrystalline cellulose
- Maize starch
- Pregelatinised maize starch
- Citric acid monohydrate
- Colloidal anhydrous silica
- Stearic acid
- Purified talc
Australian Registration Numbers
Rasazil 1 mg tablet:
AUST R 294915
Generic Health Pty Ltd
Suite 2, Level 2
19-23 Prospect Street
Box Hill, VIC, 3128
Telephone: +61 3 9809 7900
This leaflet was prepared in December 2021.
Published by MIMS April 2022