Piperacillin/ Tazobactam Kabi Injection
Piperacillin/ Tazobactam Kabi 2g/0.25g Injection & Piperacillin/ Tazobactam Kabi 4g/ 0.5 g Injection
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Piperacillin/ Tazobactam Kabi Injection. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking Piperacillin/ Tazobactam Kabi Injection against the benefits this medicine is expected to have for you.
If you have any questions about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet. You may need to read it again.
What Piperacillin/ Tazobactam Kabi Injection is used for
The name of your medicine is Piperacillin/ Tazobactam Kabi Injection. It contains the active ingredients piperacillin and tazobactam. They belong to a group of antibiotics called penicillins that work by killing bacteria.
Piperacillin is an antibiotic that kills many types of bacteria. Tazobactam belongs in the penicillin group but does not have activity against bacteria. It helps piperacillin to overcome bacteria which have become resistant to piperacillin.
Piperacillin/ Tazobactam Kabi Injection is active against bacteria which cause serious infections such as: –
- Chest infections
- Urine infections
- Stomach infections
- Skin infections
- Gynaecological infections
- Septicaemia (blood poisoning).
It is also used to treat many other infections.
In hospitalised children aged 2 to 12 years, Piperacillin/ Tazobactam Kabi Injection is used to treat serious infections in the abdomen. Piperacillin/ Tazobactam Kabi Injection is not recommended to treat abdominal infections in children under 2 years.
Piperacillin/Tazobactam Kabi Injection will not work against infections caused by viruses such as colds or flu.
This medicine is available only with a doctor’s prescription.
Piperacillin/ Tazobactam Kabi Injection is not addictive.
Before you are given Piperacillin/ Tazobactam Kabi Injection
When you must not receive Piperacillin/ Tazobactam Kabi Injection.
Do not have Piperacillin/ Tazobactam Kabi Injection if:
- you have ever had an allergic reaction to:
- piperacillin, tazobactam, or any other penicillin antibiotics
- any antibiotic in the cephalosporin group
- medicines called beta-lactamase inhibitors.
Some of the symptoms of an allergic reaction may include rash, itching or hives on the skin, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or troubled breathing.
- Piperacillin/ Tazobactam Kabi Injection should not be given to children under two years of age unless directed by the child’s doctor.
Before you start to receive Piperacillin/ Tazobactam Kabi Injection
You must tell your doctor if:
- you are allergic to any foods, dyes, preservatives or any other medicines
- you have any other health problems, including kidney or liver disease
The dose of Piperacillin/ Tazobactam Kabi Injection will be altered, depending on blood tests.
- you are on a low salt diet
- you are pregnant or plan to become pregnant
Your doctor will discuss the risks and benefits of using Piperacillin/ Tazobactam Kabi Injection if you are pregnant.
- you are breastfeeding
Piperacillin/ Tazobactam Kabi Injection passes into breast milk. Therefore, if you are breast- feeding, you should discuss with your doctor whether to stop breast- feeding while or stop using Piperacillin/ Tazobactam Kabi Injection.
- you are being treated with Piperacillin/ Tazobactam Kabi Injection for gonorrhoea, your doctor should test you for syphilis as well.
Piperacillin/ Tazobactam Kabi Injection in high doses may hide early symptoms of syphilis without curing it long-term.
If you are not sure whether you should be taking Piperacillin/ Tazobactam Kabi Injection, talk to your doctor.
Taking other medicines
Tell your doctor if you are taking any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop.
There may be interference between Piperacillin/ Tazobactam Kabi Injection and some other medicines, including:
- medicines for gout (probenicid)
- aminoglycoside antibiotics, including tobramycin
- vancomycin, an antibiotic
- preparations used for thinning blood (warfarin, heparin)
- methotrexate, used to treat cancer, rheumatoid arthritis and other inflammatory conditions
- vecuronium, a muscle relaxant used in surgery
These medicines may be affected by Piperacillin/Tazobactam Kabi Injection or may affect how well it works. You may need to be given different amounts of your medicine or you may need to be given different medicines.
If you have not told your doctor or pharmacist about any of the above, tell them before you start taking Piperacillin/ Tazobactam Kabi Injection.
How Piperacillin/ Tazobactam Kabi Injection will be given to you
How much you will be given
The dosage of Piperacillin/ Tazobactam Kabi Injection is generally 4.5g every eight hours. The dose may vary between 2.25g and 4.5 g and may also be given every six hours. For children aged 2 to 12 years, weighing up to 40 kg, and with normal kidney function, the recommended dosage is 112.5 mg/kg (100 mg piperacillin/12.5 mg tazobactam) every 8 hours. For children aged 2 to 12 years, weighing over 40 kg, and with normal kidney function, the recommended dose is 4.5 g (4 g piperacillin/0.5 g tazobactam) every 8 hours.
Your doctor may change these dosages.
If you have kidney disease your doctor will adjust the dose to suit you.
How Piperacillin/ Tazobactam Kabi Injection will be given
A doctor or nurse in hospital will always give Piperacillin/ Tazobactam Kabi Injection to you. It will usually be given to you as a slow injection into a vein over 20-30 minutes.
How long you will receive Piperacillin/ Tazobactam Kabi Injection
The length of time you will be given Piperacillin/ Tazobactam Kabi Injection depends on the type and severity of your infection. It should be given for at least five days, and for 48 hours after all signs of illness and fever have gone.
It is unlikely that you will ever receive an overdose of Piperacillin/ Tazobactam Kabi Injection because it will be given by a trained nurse or doctor.
While you are receiving Piperacillin/ Tazobactam Kabi Injection
If you receive Piperacillin/ Tazobactam Kabi Injection for a prolonged time, your doctor may wish to do some blood tests.
Sometimes blood disorders can occur if you take Piperacillin/ Tazobactam Kabi Injection.
If a doctor asks you for a urine sample, tell him/her that you are receiving Piperacillin/ Tazobactam Kabi Injection. Antibiotics in the penicillin family, including Piperacillin/ Tazobactam Kabi Injection, can cause interference in some tests for glucose in urine. Penicillins that are excreted in urine can cause a false-positive result. The doctor will request a test, which is not affected by penicillins.
Things you must do
If you develop severe diarrhoea, tell your doctor immediately. Do this even if it occurs several weeks after stopping. This may be a sign of a serious side effect that affects the bowel. You may need urgent medical care. Do not take any medicines to treat this diarrhoea without checking with your doctor.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Piperacillin/ Tazobactam Kabi Injection.
Piperacillin/ Tazobactam Kabi Injection is effective in most people, but may have unwanted side effects in some. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
The more common side effects are:
- nausea or indigestion
- diarrhoea or constipation
- rash, itchy or red skin
- allergic reactions such as hives
- a new infection caused by bacteria that are resistant to Piperacillin/ Tazobactam Kabi Injection (superinfection)
- difficulty sleeping
- headache, dizziness or light-headedness
Rare side effects are:
- increased sweating
- flaking or peeling of the skin
- inflammation of the mouth
- dry mouth
- weakness and tiredness
- muscle or joint pain or prolonged muscle relaxation
- hot flushes
- swelling of the hands, feet and ankles
- swelling or redness along a vein which is extremely tender when touched
- changes in liver function including jaundice (yellowing of skin and eyes) or hepatitis
- severe diarrhoea caused by a certain superinfection in the gut
- convulsions (‘fits’) if Piperacillin/ Tazobactam Kabi Injection is given in high doses
- short-term changes in kidney function
- cough, fever, chills, shortness of breath and chest pain
- thrush, especially with prolonged treatment.
Less often, serious effects have occurred in people taking Piperacillin/Tazobactam Kabi Injection.
Tell your doctor immediately if you notice any of the following:
- tiredness, being short of breath and looking pale
- frequent infections such as fever, severe chills, sore throat or mouth ulcers
- bleeding or bruising more easily than normal, nose bleeds
- moderate or severe skin rash or blisters often with flu-like symptoms
This is not a complete list of all possible side effects. Others may occur in some people and there may be some side effects not yet known.
Tell your doctor if you notice anything on this list or anything else that is making you feel unwell.
Importantly, tell your doctor if you have severe diarrhoea in the next few weeks after Piperacillin/ Tazobactam Kabi Injection treatment.
Do not try to treat it yourself with medicines that you can buy without a prescription.
Ask your doctor or pharmacist if you do not understand anything in this list.
Do not be alarmed by this list of possible side effects. You may not experience any of them.
After using Piperacillin/ Tazobactam Kabi Injection
It is unlikely that you will be asked to store this medication. If you are:
Keep this medicine where young children cannot reach it. A locked cupboard at least 1 and a half metres above the ground is a good place to store medicines.
Keep Piperacillin/ Tazobactam Kabi Injection in a cool, dry place where it stays below 25°C. Do not store it, or any other medicine, in a bathroom or near a sink.
Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines.
If your doctor tells you to stop taking Piperacillin/ Tazobactam Kabi Injection, or it has passed its expiry date, ask your pharmacist what to do with any left over.
What it looks like and how it is supplied
Piperacillin/ Tazobactam Kabi Injection is a white powder in glass containers (vials). The powder contains:
- 2 g of piperacillin and 250mg of tazobactam
- 4g of piperacillin and 500mg of tazobactam.
This is mixed with sterile liquid to give a solution for injection by your doctor.
Piperacillin/ Tazobactam Kabi Injection vials contain piperacillin and tazobactam as the active ingredients.
Piperacillin/ Tazobactam Kabi Injection is supplied in Australia by:
Fresenius Kabi Australia Pty Limited
Level 2, 2 Woodland Way
Mt Kuring-gai NSW 2080
Telephone (02): 9391 5555
Australian Registration Number:
- Piperacillin/Tazobactam Kabi 2g/0.25g powder for injection AUST R 311282
- Piperacillin/Tazobactam Kabi 4g/0.5 g powder for injection AUST R 311283
It is supplied in New Zealand by:
Fresenius Kabi New Zealand
Limited, 60 Pavilion Drive, Airport
Oaks, Auckland 2022, New Zealand
Freecall: 0800 144 892
Date of preparation
This leaflet was prepared in December 2019
®= Registered Trademark
Published by MIMS April 2021