Consumer medicine information


Perindopril (pronounced per-in-do-pril)

Consumer Medicine Information

(Lupin Australia Pty Ltd)


This leaflet answers some common questions about PERINDOPRIL CH. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor has weighed the risks of taking PERINDOPRIL CH against the benefits they expect it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine. You may need to read it again.


PERINDOPRIL CH is available only with a doctor’s prescription.

PERINDOPRIL CH lowers high blood pressure, a condition which doctors call hypertension.

Everyone has blood pressure. This pressure helps get your blood all around the body.

Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have high blood pressure when your blood pressure stays higher than is needed, even when you are calm or relaxed.

There are usually no symptoms of high blood pressure. The only way of knowing that you have it is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually it can cause stroke, heart disease and kidney failure. PERINDOPRIL CH helps lower your blood pressure.

You may be prescribed PERINDOPRIL CH for heart failure. Heart failure means that the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops working. Some people develop heart failure after having had a heart attack. However there are also other causes of heart failure.

Heart failure may start off with no symptoms, but as the condition progresses, you may feel short of breath or may get tired easily after light physical activity such as walking. You may wake up short of breath at night. Fluid may collect in different parts of the body, often first noticed as swollen ankles and feet. In severe heart failure, symptoms may occur even at rest.

PERINDOPRIL CH helps to treat heart failure. If you follow your doctor’s advice, your ability to perform daily activities may improve. You may breath more easily, feel less tired, and have less swelling.

You may also have been prescribed PERINDOPRIL CH if you have coronary artery disease. Coronary artery disease is narrowing of the vessels carrying blood to the heart. In patients with coronary artery disease, PERINDOPRIL CH has been shown to reduce some of the risks, including heart attacks.


There are some people who shouldn’t take PERINDOPRIL CH.

Please read the list below. If you think any of these situations apply to you or you have any questions, please consult your doctor.


Do not take PERINDOPRIL CH if:

  • you are pregnant or trying to become pregnant
  • you are breastfeeding or plan to breastfeed
  • you undergo renal dialysis using polyacrylonitrile membranes
  • you have renal artery stenosis stenosis (a problem with the blood vessels to one or both kidneys)
  • you have experienced swelling of the face, tongue, lips or throat either spontaneously or in response to another medicine in the past. (This rare condition is known as angio-oedema)
  • you are allergic to it or any of the ingredients listed at the end of this leaflet
  • the packaging is torn or shows sign of tampering
  • the expiry date (EXP) on the pack has passed.

Tell your doctor straight away if:

  • You become pregnant while you are taking PERINDOPRIL CH
  • You are undergoing desensitisation treatment, or have had an allergic reaction during previous desensitisation treatment (e.g. treatments using bee, wasp or ant venom)
  • You are undergoing, or have had an allergic reaction during previous, low-density lipoprotein (LDL) apheresis, a technique where LDL is ‘filtered’ out of a patient’s blood, using dextran sulphate
  • If you are to undergo anaesthesia and/or surgery
  • If you have recently suffered from diarrhoea or vomiting
  • You have any other health problems, including:
    – Kidney disease
    – Liver disease
    – High or low levels of potassium, or other problems with salt balance
    – Diabetes
    – Heart disease.

PERINDOPRIL CH can generally be used safely by elderly people. However reduced kidney function is often found in elderly people and in this case, the starting dose should always be 2 mg. PERINDOPRIL CH is not recommended for children.

If you think any of these situations apply to you, or you have any doubts or questions about taking PERINDOPRIL CH consult your doctor or pharmacist.

Taking other medicines

Taking PERINDOPRIL CH may change the effect of some medicines, and some medicines may affect how well PERINDOPRIL CH works. You may need different amounts of your medication or to take different medicines.

The medicines that may interact with PERINDOPRIL CH include the following:

  • Some antibiotic drugs
  • Some antiinflammatory drugs
  • Lithium medications (used to treat mood swings and some types of depression)
  • Potassium-sparing diuretics, sources of potassium, like potassium tablet and salt substitutes containing potassium.
  • Some medications used to treat high blood pressure (including diuretics sometimes called ‘fluid’ or ‘water’ tablets because they increase the amount of urine passed each day), a fast or irregular heartbeat, and other heart conditions
  • Medicines used to treat diabetes (tablets and insulin).

It is a good idea to remind your doctor of all other medicines you take. Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking PERINDOPRIL CH.


The dose of PERINDOPRIL CH you may need each day will be decided and adjusted by your doctor. This will normally be 2 mg, 4 mg or 8 mg once daily for high blood pressure and for people with coronary artery disease, and 2 mg to 4 mg once daily for heart failure.

Swallow your tablet(s) with a glass of water, preferably in the morning before a meal.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and then go back to taking it as you would normally.

Do not take a double dose to make up for the dose that you missed.

How long to take it

PERINDOPRIL CH helps control your blood pressure or your heart failure, but does not cure it. Continue taking the tablets for as long as your doctor tells you.

If you take too much

Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26) if you think you or anyone else may have taken too much PERINDOPRIL CH. Do this even if there are no signs of discomfort or poisoning.


Things you must not do

Do not give PERINDOPRIL CH to anyone else, even if they have the same condition as you.

Do not use PERINDOPRIL CH to treat other complaints unless your doctor tells you to.

Do not stop taking PERINDOPRIL CH or change the dosage, without checking with your doctor.

Do not stop taking your tablets because you are feeling better, unless advised by your doctor.


PERINDOPRIL CH helps most people with high blood pressure, heart failure or coronary artery disease, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious, most of the time they are not.

With PERINDOPRIL CH, the side effects can include:

  • cough, often described as dry and irritating
  • headache, dizziness, vertigo, paraesthesia
  • tinnitus, vision disturbances
  • hypotension
  • feeling tired or lethargic
  • nausea or stomach pain
  • muscle cramps
  • rash, pruritus.

These side effects when they occur are usually mild.

Consult your doctor or pharmacist if you experience any of these or notice anything else that is making you fell unwell.

Do not be alarmed by this list of possible side effects. You may not experience any of them. Other uncommon side effects have been reported and you should ask your doctor or pharmacist if you want to know more.

If any of the signs below occur then tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital:

  • Swelling of your lips, face, mouth, tongue or throat.
  • A fast and irregular heart beat.
  • Difficulty in breathing.
  • Severe blisters, skin rash, itching or other allergic reactions.

These side effects are extremely rare but can become serious.



Heat and dampness can destroy some medicines.

Keep your tablets in the pack until it is time to take them.

Keep them in a cool, dry place where it stays below 30 degrees Celcius.

Do not store medicines in a bathroom or near a sink. Do not leave them in a car or on a windowsill.

Keep them where children cannot reach them.


If your doctor tells you to stop taking PERINDOPRIL CH, or the tablets have passed their expiry date, return any leftover tablets to your pharmacist for disposal.


Australian Register Numbers:
PERINDOPRIL CH 2 mgtablets: AUST R 125447
PERINDOPRIL CH 4 mg tablets: AUST R 125449
PERINDOPRIL CH 8 mg tablets: AUST R 125450

What PERINDOPRIL CH looks like

  • PERINDOPRIL CH tablets 2 mg are white to off-white, round, biconvex tablets, plain on one side and debossed with ‘2’ on the other side and contain 2 mg of perindopril erbumine.
  • PERINDOPRIL CH tablets 4 mg are white to off-white, capsule shaped tablets, with breakline on one side and debossed with ‘4’ and ‘4’ on either side of the breakline on the other side and contain 4 mg of perindopril erbumine.

PERINDOPRIL CH tablets 8 mg are white to off-white, round, biconvex tablets, plain on one side and debossed with ‘8’ on the other side and contain 8 mg of perindopril erbumine.

PERINDOPRIL CH 2 mg, PERINDOPRIL CH 4 mg and PERINDOPRIL CH 8 mg are contained in a blister strip that is itself enclosed in an aluminium foil envelope containing a desiccant sachet. Each carton contains 30 tablets. A desiccant is a substance that absorbs moisture and helps to protect the tablets, especially when it is very humid.


Each PERINDOPRIL CH tablet contains perindopril erbumine as the active ingredient as well as the inactive microcrystalline cellulose, lactose, magnesium stearate and silica dimethyl silylate.


Amneal Pharma Australia Pty Ltd
12 River Street
South Yarra, Victoria 3141

This document was last revised in May 2014.

Published by MIMS January 2015