Consumer medicine information

Nurofen® Plus Tablets


Limitations of use

Nurofen Plus should only be used when your doctor decides that other treatment options are not able to effectively manage your pain or you cannot tolerate them.

Hazardous and harmful use

Nurofen Plus poses risks of abuse, misuse and addiction which can lead to overdose and death. Your doctor will monitor you regularly during treatment.

Life threatening respiratory depression

Nurofen Plus can cause life-threatening or fatal breathing problems (slow, shallow, unusual or no breathing) even when used as recommended. These problems can occur at any time, but the risk is higher when first starting Nurofen Plus and after a dose increase, if you are older, or have an existing problem with your lungs. Your doctor will monitor you and change the dose as appropriate.

Use of other medicines while taking Nurofen Plus

Using Nurofen Plus with other medicines that can make you feel drowsy such as sleeping tablets (e.g. benzodiazepines), other pain relievers, antihistamines, antidepressants, antipsychotics, gabapentinoids (e.g. gabapentin and pregabalin), cannabis oil and alcohol may result in severe drowsiness, decreased awareness, breathing difficulties, coma and death. Your doctor will minimise the dose and duration of use and monitor you for signs and symptoms of breathing difficulties and sedation. You must not drink alcohol while using Nurofen Plus

Nurofen® Plus Tablets

Active ingredients: Ibuprofen 200mg and Codeine phosphate hemihydrate 12.8mg

Consumer Medicine Information (CMI)

This leaflet provides important information about using Nurofen Plus. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using Nurofen Plus.

Where to find information in this leaflet:

1. Why am I using Nurofen Plus?
2. What should I know before I use Nurofen Plus?
3. What if I am taking other medicines?
4. How do I use Nurofen Plus?
5. What should I know while using Nurofen Plus?
6. Are there any side effects?
7. Product details

1. Why am I using Nurofen Plus?

Nurofen Plus contains the active ingredients Ibuprofen and Codeine phosphate. Ibuprofen belongs to a family of medicines called non-steroidal anti-inflammatory drugs (NSAIDS). These medicines work by relieving pain and/or inflammation (swelling, redness, soreness) and fever. Codeine is an opioid analgesic that works in the brain and spinal cord to relieve pain.

Nurofen Plus is used to provide temporary relief of acute moderate pain and inflammation in patients over the age of 12 years.

After taking codeine, the body changes codeine into the active morphine by a special liver enzyme. However, about 8% of people may experience less pain relief compared to others, as their bodies do not change codeine to morphine as well as others.

2. What should I know before I use Nurofen Plus?


Do not give Nurofen Plus to children under the age of 12 years.

Do not use Nurofen Plus if:

  • you are allergic to ibuprofen, codeine, other opioids, or any medicine containing ibuprofen, aspirin or other NSAIDs or any of the ingredients listed at the end of this leaflet.

Many medicines used to treat headache, period pain and other aches and pains contain aspirin or NSAIDs. If you are not sure if you are taking any of these medicines, ask your pharmacist.

Always check the ingredients to make sure you can use this medicine.

Symptoms of an allergic reaction to these medicines may include:

  • asthma, wheezing or shortness of breath.
  • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing.
  • hives, itching or skin rash.
  • fainting.

If you are allergic to aspirin or NSAIDs and take Nurofen Plus these symptoms may be severe.

  • you are in the last three months of pregnancy or are breast-feeding.
  • you are vomiting blood or material that looks like coffee grounds
  • you are bleeding from the rectum (back passage), have black sticky bowel motions (stool) or bloody diarrhoea
  • you have peptic ulcer (i.e. stomach or duodenal ulcer) or have had one before.
  • you are using other NSAIDS
  • you have chronic constipation or shallow breathing, or severe diarrhoea.
  • You consume regular and heavy amounts of alcohol.
  • You are a CYP2D6 ultra-rapid metaboliser.
  • If you have severe liver impairment
  • If you have heart or kidney problems
  • If you are currently taking a Monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping treatment with a MAOI.

Do not take Nurofen Plus if the packaging is torn or shows signs of tampering.

Do not take Nurofen Plus if the expiry date (EXP) printed on the pack has passed.

If you take this medicine after the expiry date has passed, it may not work as well.

Do not give Nurofen Plus to children under 12 years or to those aged 12 -18 years in whom respiratory function may be compromised.

Check with your doctor if you:

  • have or have had any other medical conditions:
  • difficulty breathing, wheezing, chronic cough, allergies, asthma or other breathing conditions
  • a history of drug dependence, including alcohol dependence
  • skin rash (dermatitis)
  • skin irritation
  • a history of stomach ulcer.
  • liver disease.
  • kidney disease.
  • heart problems/failure, including. swelling of ankles or feet.
  • Thyroid problems or low blood pressure.
  • a head injury or intracranial pressure.
  • prostatic problems.
  • stomach problems or recent stomach surgery.

Tell your doctor if you take sedatives (medicines used to help you relax or sleep).

Tell your doctor if you have allergies to:

  • any other medicines including aspirin, or other NSAID medicines.
  • any other substances, such as foods, preservatives or dyes.

If you have not told your doctor about any of the above, tell him/her before you start taking Nurofen Plus.

During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?

Pregnancy and breastfeeding

Check with your doctor if you are pregnant or intend to become pregnant.

Nurofen Plus is not recommended during the last 3 months of pregnancy. Your doctor will decide if you should take Nurofen Plus during the first 6 months of pregnancy.

Talk to your doctor if you are breastfeeding or intend to breastfeed.

Nurofen Plus should not be taken while breastfeeding.


You can become addicted to Nurofen Plus even if you take it exactly as prescribed. Nurofen Plus may become habit forming causing mental and physical dependence. If abused it may become less able to reduce pain.


As with all other opioid containing products, your body may become used to you taking Nurofen Plus. Taking it may result in physical dependence. Physical dependence means that you may experience withdrawal symptoms if you stop taking Nurofen Plus suddenly, so it is important to take it exactly as directed by your doctor.


Tolerance to Nurofen Plus may develop, which means that the effect of the medicine may decrease. If this happens, more may be needed to maintain the same effect.

3. What if I am taking other medicines?

Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines may interfere with Nurofen Plus and affect how it works.

These include:

  • medicines used to help you relax, sleep or relieve anxiety, such as barbiturates and sedatives.
  • aspirin, salicylates or other NSAID medicines.
  • Warfarin or other medicines used to prevent blood clots.
  • medicines that are used to treat high blood pressure including diuretics (fluid tablets)
  • methotrexate.
  • zidovudine.
  • lithium
  • mifeprisone, quinolone antibiotics
  • medicines used to relieve stomach cramps, prevent travel sickness and to treat Parkinson’s disease.
  • medicines used to treat diarrhoea (e.g. kaolin, pectin, loperamide).
  • metoclopramide, a medicine used to treat nausea and vomiting
  • Medicines that affect serotonin levels (serotonergic medicines)
  • selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAOIs), medicines used to treat some types of depression
  • quinidine, a medicine used to treat abnormal or irregular heart beat
  • phenothiazines and antipsychotic agents, medicines used to treat mental disorders
  • medicines such as cyclosporin, tacrolimus, prednisone, prednisolone and cortisone which reduce the activity of your immune system
  • probenecid-medicines used to treat gout
  • phenytoin – medicine used to treat epilepsy
  • other opioid pain killers.

These medicines may be affected by Nurofen Plus or may affect how well it works. You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.

Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect Nurofen Plus.

4. How do I use Nurofen Plus?

Follow all directions given to you by your pharmacist or doctor carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions on the pack, ask your pharmacist or doctor for help.

How much to take and when to take it

  • The usual dose of Nurofen Plus is 2 tablets then, if necessary 1 or 2 tablets every 4 to 6 hours. Do not take more than six tablets in 24 hours.
  • Follow the instructions provided and use Nurofen Plus until your doctor tells you to stop.

How to take it

  • Take Nurofen Plus by mouth with fluid. It may also be taken with or immediately after food.

How long to take it

  • You should not take Nurofen Plus for more than three days at a time.

If your symptoms persist, worsen or new symptoms develop, talk to your doctor.

Talk to your doctor about pain control if Nurofen Plus is not helping.

Depending on your body’s individual ability to break down codeine, you may be getting reduced benefit or experience signs of overdose even when you take Nurofen Plus as recommended by your doctor. If overdose symptoms occur, seek immediate medical advice.

If you use too much Nurofen Plus

If you or someone else receive too much (overdose), and experience one or more of the symptoms below, immediately and call triple zero (000) for an ambulance. Keep the person awake by talking to them or gently shaking them every now and then. You should follow the above steps even if someone other than you have accidentally used Nurofen Plus that was prescribed for you. If someone takes an overdose they may experience one or more of the following symptoms:

  • Slow, unusual or difficult breathing
  • Drowsiness, dizziness or unconsciousness
  • Slow or weak heartbeat
  • Nausea or upset stomach, vomiting and/or gastric irritation
  • Convulsions, fits or unconsciousness
  • Excitability
  • Blurred vision, ringing in the ears, or rapid uncontrollable movements of the eyes.

If you think you or someone else may have used too much Nurofen Plus, you should immediately:

  • phone the Poisons Information Centre (by calling 13 11 26), or
  • contact your doctor, or
  • go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.

When seeking medical attention, take this leaflet and remaining medicine with you to show the doctor. Also tell them about any other medicines or alcohol which have been taken.

5. What should I know while using Nurofen Plus?

Things you should do

  • If you are about to be started on any new medicine tell your doctor and pharmacist that you are taking Nurofen Plus.
  • Remind any doctor, dentist or pharmacist you visit that you are using Nurofen Plus.
  • If you are going to have surgery, tell your doctor you are taking Nurofen Plus.

Talk to doctor if your symptoms do not improve.

Your doctor will assess your condition and decide if you should continue to take the medicine.

Call your doctor straight away if you:

  • Become pregnant while taking Nurofen Plus

Things you should not do

  • Do not take high doses of the medicine for long periods of time unless your doctor tells you to. Products containing codeine should not be taken for prolonged periods. Codeine may be habit forming.
  • Do not give Nurofen Plus to anyone else, even if they have the same condition as you.
  • Do not use Nurofen Plus to treat any other complaints unless your doctor tells you to.
  • Do not take more than the recommended dose unless your doctor tells you to.
  • Excessive use can be harmful and increase the risk of heart attack, stroke or liver damage.

Driving or using machines

Be careful before you drive or use any machines or tools until you know how Nurofen Plus affects you.

Nurofen Plus may cause dizziness light-headedness or drowsiness in some people. If this occurs, do not drive or operate machinery. If you drink alcohol, dizziness, light-headedness and/or drowsiness may be worse.

Drinking alcohol

Tell your doctor if you drink alcohol.

Using Nurofen Plus with alcohol may result in severe drowsiness, decreased awareness, breathing difficulties, coma and death.


Continue taking your medicine for as long as your doctor tells you. If you stop having this medicine suddenly, your pain may worsen and you may experience some or all of the following withdrawal symptoms:

  • nervousness, restlessness, agitation, trouble sleeping or anxiety
  • body aches, weakness or stomach cramps
  • loss of appetite, nausea, vomiting or diarrhoea
  • increased heart rate, breathing rate or pupil size
  • watery eyes, runny nose, chills or yawning
  • increased sweating.

Nurofen Plus given to the mother during labour can cause breathing problems and signs of withdrawal in the newborn.

Looking after your medicine

  • Keep the tablets in the original pack until it is time to take the dose. If you take them out they will not keep well.

Follow the instructions in the carton on how to take care of your medicine properly.

Store it in a cool dry place where the temperature stays below 25°C away from moisture, heat or sunlight; for example, do not store it:

  • in the bathroom or near a sink, or
  • in the car or on window sills.

Heat and dampness can destroy some medicines.

Keep medicines where children cannot reach them

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Getting rid of any unwanted medicine

If you no longer need to use this medicine or it is out of date, take it to any pharmacy for safe disposal.

Do not use this medicine after the expiry date.

6. Are there any side effects?

All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.

See the information below and, if you need to, ask your doctor or pharmacist if you have any further questions about side effects.

Less serious side effects

Less serious side effects What to do
Gastrointestinal related:

  • stomach upset including nausea (feeling sick), vomiting
  • heartburn, indigestion
  • constipation
  • diarrhoea, pain in the stomach
  • loss of appetite

Head and neurology related:

  • sleeplessness, nightmares
  • change in mood e.g. depression, restlessness, irritability
  • sore or dry mouth or tongue
  • dizziness, light-headedness, drowsiness
  • headache
  • hearing disturbance
  • central sleep aponea

Respiratory related:

  • shallow breathing
  • cough suppression
Speak to your doctor if you have any of these less serious side effects and they worry you.

Serious side effects

Serious side effects What to do
Gastrointestinal related:

  • severe pain or tenderness in the stomach
  • vomiting blood or material that looks like coffee grounds.
  • bleeding from the back passage, black sticky bowel motions (stools) or bloody diarrhoea.

Allergy related:

  • shallow breathing or shortness of breath
  • flushing of the face
  • swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing.
  • asthma, wheezing, shortness of breath, pain or tightness in the chest
  • symptoms of sunburn (such as redness, itching, swelling, blistering) which may occur more quickly than normal

Heart related:

  • fast heart beat

Skin related:

  • yellowing of the skin and eyes, also called jaundice
  • sudden or severe itching, skin rash, hives, skin peeling

Urinary related:

  • a change in the colour of urine passed, blood in the urine
  • a change in the amount or frequency of urine passed, burning feeling when passing urine
  • unusual weight gain, swelling of ankles or legs

Infection related:

  • signs of frequent or worrying infections such as fever, severe chills, sore throat or mouth ulcers

Bleeding related:

  • bleeding or bruising more easily than normal, reddish or purplish blotches under the skin
  • signs of anaemia, such as tiredness, being short of breath, and looking pale

Head and neurology related:

  • unusual or extreme mood swings
  • dizziness, light-headedness
  • severe dizziness, spinning sensation
  • severe or persistent headache
  • difficulty hearing, deafness
  • tingling or numbness of the hands or feet

Eyes related:

  • eye problems such as blurred vision, sore red eyes, itching
Call your doctor straight away, or go straight to the Emergency Department at your nearest hospital if you notice any of these serious side effects.

Tell your doctor or pharmacist if you notice anything else that may be making you feel unwell.

Other side effects not listed here may occur in some people.

Reporting side effects

After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at By reporting side effects, you can help provide more information on the safety of this medicine.

Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines.

7. Product details

This medicine is only available with a doctor’s prescription.

What Nurofen Plus contains

Active ingredient
(main ingredient)
Ibuprofen and Codeine phosphate hemihydrate
Other ingredients
(inactive ingredients)
Microcrystalline cellulose, Sodium starch glycollate, Hypromellose, Pregelatinised maize starch, Talc, Opaspray white colouring
Potential allergens Nurofen Plus is gluten-free and lactose-free

Do not take this medicine if you are allergic to any of these ingredients.

What Nurofen Plus looks like

Nurofen Plus tablets are white capsule shaped tablets marked ‘N+’ on one side. (AUST R 116620).

Nurofen Plus is available in blister packs of *4, *6, *12, *24 & 30 tablets.

*not available in Australia

Who distributes Nurofen Plus

Reckitt Benckiser, Sydney NSW, Australia

This leaflet was prepared in November 2022.