Clopidogrel (as besilate)
Consumer Medicine Information
Please read this leaflet carefully before you start to take Clopidogrel-PS.
What is in this leaflet
This leaflet answers some common questions about this medicine.
It does not contain all the available information. Some of the information it contains may not apply to you.
It does not take the place of talking to your doctor or pharmacist.
All medicines have benefits and risks. In deciding to give you Clopidogrel-PS, your doctor has weighed the risks of you taking Clopidogrel-PS against the benefits it will have for you.
Always follow the instructions that your doctor and pharmacist give you about Clopidogrel-PS.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine. . You may need to read it again
What Clopidogrel-PS is used for
Clopidogrel-PS contains the medicine clopidogrel. Clopidogrel belongs to a group of medicines known as antiplatelet medicines.
Platelets are very small blood cells which clump together during blood clotting. By preventing this clumping, antiplatelet medicines reduce the chances of blood clots forming (a process called thrombosis).
Clopidogrel-PS is used to prevent blood clots forming in hardened blood vessels as they can lead to events such as stroke, heart attack or death.
You have been prescribed Clopidogrel-PS to help prevent blood clots forming and to reduce the risk of stroke, heart attack and death because:
- You have previously suffered a heart attack, stroke or have a condition known as peripheral arterial disease (leg pain on walking or at rest)
Your doctor may have prescribed this medicine for another use. If you want more information, ask your doctor.
Clopidogrel-PS is only available on a doctor’s prescription.
Before you take Clopidogrel-PS
When you must not take it
You should not take Clopidogrel-PS if:
- you are allergic to clopidogrel, or to any of the ingredients listed under ‘Product Description’ at the end of this leaflet
- you have a medical condition that is causing bleeding such as a stomach ulcer
- you have any bleeding within your head
- you suffer from severe liver disease
- you are breast feeding or intend to breast feed
Clopidogrel-PS passes into breast milk and, therefore, there is the possibility that the breast fed baby may be affected.
- the packaging shows signs of tampering
- the expiry date on the pack has passed
Clopidogrel-PS is not recommended for children because the safety and effectiveness of Clopidogrel-PS in children have not been established.
Before you start to take it
You must tell your doctor if:
- you are pregnant or intend to become pregnant
Your doctor will discuss the possible risks and benefits of taking Clopidogrel-PS during pregnancy.
- you are planning to have an operation (including dental surgery) in the next two weeks
Your doctor will decide whether or not you need to stop Clopidogrel-PS prior to surgery.
- if you have or have had any medical conditions, especially the following:
- bleeding disorders or blood clotting problems
- any illness or disability that was caused by bleeding for example impaired sight or vision because of bleeding within the eye
- recent serious injury
- recent surgery (including dental surgery)
- any form of liver disease
If you have not told your doctor about any of the above, tell him/her before you start taking Clopidogrel-PS.
Taking other medicines
Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food store.
Some medicines and Clopidogrel-PS may interfere with each other. These include:
- medicines that ‘thin the blood’. The most common examples of these include aspirin, heparins and warfarin. There are other medicines used to ‘thin the blood’.
Check with your doctor or pharmacist to see if any medicine you take may have this effect.
- non-steroidal anti-inflammatory drugs (NSAIDS) – medicines used to treat arthritis, period pain, aches and pains
- phenytoin – a medicine used to treat epilepsy
- tolbutamide – a medicine used to treat diabetes
- fluvastatin – a medicine used to lower cholesterol
- tamoxifen – a medicine used to treat breast cancer
These medicines may be affected by Clopidogrel-PS or affect how well it works. Your doctor may need to change the amount of your medicines, or you may need to take different medicines.
If you are unsure about any medicine you are taking you should check with your doctor or pharmacist. They will have more information on medicines to be careful with or avoid while taking Clopidogrel-PS.
How to take Clopidogrel-PS
Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.
How much to take
The usual dose of Clopidogrel-PS is one 75 mg tablet daily.
If you do not understand the instructions on the box ask your doctor or pharmacist for help.
How to take it
Swallow the Clopidogrel-PS tablet with a glass of water.
When to take it
You can take Clopidogrel-PS before or after meals.
Take Clopidogrel-PS at about the same time each day. Taking your tablet at the same time each day will have the best effect. It will also help you to remember when to take it.
If you forget to take it
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the dose you missed, and take your next dose when you are meant to.
If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.
If you take too much (overdose)
Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26) for advice, or go to Emergency Department at your nearest hospital, if you think that you or anyone else may have taken too much Clopidogrel-PS. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
While you are taking Clopidogrel-PS
Things you must do
Take Clopidogrel-PS exactly as your doctor has prescribed, and have any blood tests promptly when your doctor recommends that tests be done.
Tell your doctor:
- if you become pregnant while taking Clopidogrel-PS
- if you decide to breast feed your baby
Your doctor may want to discuss your decision and change your medicine.
- that you are taking Clopidogrel-PS if you are about to start on any new medicine
- and dentists, nurses or pharmacists that you are taking Clopidogrel-PS
Clopidogrel-PS may increase the risk of bleeding during an operation or some dental work. Therefore, treatment may need to be stopped before surgery. Your doctor will decide whether to stop Clopidogrel-PS and if so, how long before surgery.
- immediately if you are injured while taking Clopidogrel-PS.
It may take longer than usual to stop bleeding while you are taking Clopidogrel-PS.
- immediately if you notice any of the following:
abnormal bruising or bleeding; abnormal nose bleeds; red or purple blotches on your skin; bloody or black bowel motions; swelling of the face, lips, mouth, tongue or throat which may cause difficulty swallowing or breathing. (See also Side Effects section).
Things you must not do
There are activities you should avoid while taking Clopidogrel-PS, for example certain sports. Sometimes after an injury bleeding may occur inside your body without you knowing about it. Ask your doctor for advice. Do not take Clopidogrel-PS to treat any other complaint unless your doctor says it is safe. Do not give this medicine to anyone else. Do not suddenly stop taking Clopidogrel-PS without telling your doctor.
Things to be careful of
Be careful driving or operating machinery until you know how Clopidogrel-PS affects you. As with other medicines Clopidogrel-PS may cause faintness or dizziness in some people. Make sure you know how you react to Clopidogrel-PS before you drive a car, operate machinery, or do anything else that could be dangerous if you are faint or dizzy. If this occurs do not drive. If you drink alcohol faintness or dizziness may be worse.
Tell your doctor or pharmacist as soon as possible if you do not feel well while taking Clopidogrel-PS.
Like other medicines Clopidogrel-PS can cause some side effects. Most are likely to be minor and temporary. However, some may be serious and need medical attention.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of the following and they worry you:
- pain or stiffness in the joints
- things taste different
Tell your doctor immediately if you notice any of the following:
(NOTE: If you take both Clopidogrel-PS and aspirin the risk of side effects related to bleeding may be increased)
- bloody or black bowel motions
- diarrhoea with blood and mucus, stomach pain and fever
- abdominal or stomach pain
- nausea, vomiting, weight loss
- vomiting of blood or vomit that looks like coffee grounds
- coughing of blood
- blood in the urine
- bleeding in eyes
- unusually heavy bleeding or oozing from cuts or wounds
- unusually heavy or unexpected menstrual bleeding
- bleeding (including nose bleeds) or bruising more easily than normal
- itching, inflamed, cracking or red skin
- red or purple spots visible through your skin
- anaemia (being tired and looking pale)
- numbness (paralysis) or problems with co-ordination
- fever, muscle weakness, loss of appetite and fatigue
- muscle pain
- faintness, dizziness, lightheadedness or blurred vision
- confusion or hallucinations
- slurred speech or other difficulty in speaking
- tightness of the chest, wheezing, coughing or difficulty breathing
- headache (severe and continuing)
- fever or other signs of infection, such as a sore throat
- swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing
- chills, sweating or clammy skin
- yellowing of the skin or whites of the eyes, vomiting, pale stools, dark urine and stomach pain with swelling
These could be more serious side effects – you may need urgent medical attention.
Other side effects not listed above may also occur in some patients. Tell your doctor if you notice any other effects.
After using Clopidogrel-PS
Keep your tablets in the blister pack until it is time to take them. If you take your tablets out of the box or blister pack they will not keep well.
Keep Clopidogrel-PS in a cool, dry place where the temperature stays below 25°C. Protect from light.
Do not store Clopidogrel-PS or any other medication in the bathroom or near a sink. Do not leave Clopidogrel-PS in the car on hot days. Heat and dampness can destroy some medicines.
Keep Clopidogrel-PS where young children cannot reach it. A locked cupboard at least one and a half metres above the ground is a good place to store medicines.
If your doctor tells you to stop taking Clopidogrel-PS, ask your pharmacist what to do with any medicine that is left over.
What it looks like
Clopidogrel-PS 75 mg tablets are pink coloured, round biconvex film coated with a smooth surface
The active ingredient in Clopidogrel-PS 75 mg tablets is clopidogrel besilate.
The inactive (excipient) ingredients are:
- Cellulose – microcrystalline
- Silica – colloidal anhydrous
- Stearic acid
- Titanium dioxide
- Iron oxide red.
Ascent Pharma Pty Ltd
151-153 Clarendon Street
South Melbourne VIC 3205
AUST R 162329
Date of preparation: March 2012
Published by MIMS May 2012