Consumer medicine information



Active ingredient(s): procaine benzylpenicillin (procaine penicillin)

Consumer Medicine Information (CMI)

This leaflet provides important information about using CILICAINE SYRINGE 1.5. You should also speak to your doctor or pharmacist if you would like further information or if you have any concerns or questions about using CILICAINE SYRINGE 1.5.

Where to find information in this leaflet:

1. Why am I using CILICAINE SYRINGE 1.5?
2. What should I know before I use CILICAINE SYRINGE 1.5?
3. What if I am taking other medicines?
4. How do I use CILICAINE SYRINGE 1.5?
5. What should I know while using CILICAINE SYRINGE 1.5?
6. Are there any side effects?
7. Product details

1. Why am I using CILICAINE SYRINGE 1.5?

CILICAINE SYRINGE 1.5 contains the active ingredient procaine benzylpenicillin (procaine penicillin). CILICAINE SYRINGE 1.5 is an antibiotic belonging to the group of antibiotics known as penicillins.

CILICAINE SYRINGE 1.5 is used to treat infections in different parts of the body caused by bacteria. It works by killing the bacteria that are causing the infection. It will not work against infections caused by viruses such as colds or the flu.

Ask your doctor if you have any questions about why this medicine has been prescribed for you.

Your doctor may have prescribed it for another reason.

This medicine is available only with a doctor’s prescription.

2. What should I know before I use CILICAINE SYRINGE 1.5?


Do not use CILICAINE SYRINGE 1.5 if:

  • you are allergic to any medicine containing procaine benzylpenicillin, any other penicillin medicines or any of the ingredients listed at the end of this leaflet.

Always check the ingredients to make sure you can use this medicine.

  • the expiry date (EXP) printed on the pack has passed or the packaging is torn or shows signs of tampering.

You must tell your doctor if you have had an allergic reaction to cephalosporins.

You may have an increased chance of being allergic to CILICAINE SYRINGE 1.5 if you are allergic to cephalosporins.

Some of the symptoms of an allergic reaction may include:

  • shortness of breath
  • wheezing or difficulty breathing
  • swelling of the face, lips, tongue or other parts of the body
  • rash, itching or hives on the skin

Tell your doctor if you have suffered from any other allergic reactions in the past due to use of penicillin.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Check with your doctor if you:

  • have allergies to any other medicines, foods, preservatives or dyes.
  • are taking probenecid, a medicine used to treat gout.
  • take the oral contraceptive pill. Talk to your doctor or nurse about the need to use additional contraception whilst being given CILICAINE SYRINGE 1.5.

Some antibiotics may decrease the effectiveness of some birth control pills, though this has not been shown in CILICAINE SYRINGE 1.5.

If you have not told your doctor about any of the above, tell them before you are given CILICAINE.

During treatment, you may be at risk of developing certain side effects. It is important you understand these risks and how to monitor for them. See additional information under Section 6. Are there any side effects?

Pregnancy and breastfeeding

Do not receive this medicine if you are pregnant.

It may affect your developing baby if you take it during pregnancy.

Do not breast-feed if you are taking this medicine.

Your doctor will discuss with you the risks and benefits of being given CILICAINE SYRINGE 1.5 during pregnancy and when you are breastfeeding.

3. What if I am taking other medicines?

Tell your doctor or pharmacist if you are taking any other medicines, including any medicines, vitamins or supplements that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and CILICAINE SYRINGE 1.5 may interfere with each other.

You may need different amounts of your medicines, or you may need to take different medicines.

Your doctor and nurse have more information on medicines to be careful with or avoid whilst you are receiving CILICAINE SYRINGE 1.5.

Check with your doctor or pharmacist if you are not sure about what medicines, vitamins or supplements you are taking and if these affect CILICAINE SYRINGE 1.5.

4. How do I use CILICAINE SYRINGE 1.5?

CILICAINE SYRINGE 1.5 is given as a deep injection into a large muscle.

CILICAINE SYRINGE 1.5 must only be given by a doctor or nurse.

How much is given

The usual dose is:


1.5 g daily for two to five days.

For the treatment of gonorrhoea or syphilis:

1 g daily for 7 to 14 days or up to 4.8 g as a single session treatment usually administered with probenecid.


1/4 or 1/2 adult dose is usually sufficient for children under 3 or over 3 years of age, respectively.

How long to use it for

Your doctor will tell you how long you will be given CILICAINE SYRINGE 1.5 injections for.

The whole course must be given. Do not stop receiving CILICAINE SYRINGE 1.5 even if you feel better.

Your infection and symptoms may return.

If you forget to be given CILICAINE SYRINGE 1.5

If you have forgotten about your next CILICAINE SYRINGE 1.5 injection, go to your doctor as soon as you remember and then go back to your normal visits.

If you use too much CILICAINE SYRINGE 1.5

As this medicine is given to you by a doctor or nurse it is unlikely that you will receive too much.

You should immediately:

  • phone the Poisons Information Centre
    (Australia telephone 13 11 26) for advice, or
  • contact your doctor, or
  • go to the Emergency Department at your nearest hospital.

You should do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention

5. What should I know while using CILICAINE SYRINGE 1.5?

Things you should do

  • If you are about to be started on any new medicine, remind your doctor and pharmacist that you are currently receiving CILICAINE SYRINGE 1.5.
  • Tell any other doctors, dentists and pharmacists who treat you that you are receiving this medicine.
  • If your symptoms do not improve within few days, or if they become worse, tell your doctor.
  • If you develop any form of skin rash and/or itching or difficulty in breathing while using CILICAINE SYRINGE 1.5, contact your doctor immediately.
  • If you develop severe diarrhoea tell your doctor immediately.

Do this even if it occurs several weeks after you have stopped using CILICAINE SYRINGE 1.5.

  • If you become pregnant while receiving this medicine, tell your doctor immediately.
  • If you are about to have any blood tests, tell your doctor that you are being given this medicine.

It may interfere with the results of some tests.

  • Tell your doctor if you have not received this medicine as it was prescribed.

Otherwise your doctor may think that it was not effective and change your treatment unnecessarily.

  • Keep all of your doctor’s appointments so that your progress can be checked.

Things you should not do

  • Do not use CILICAINE SYRINGE 1.5 to treat any other complaints unless your doctor tells you to.
  • Do not give your medicine to anyone else, even if they have the same condition as you.
  • Do not stop taking your medicine or lower the dosage without checking with your doctor.

Things to be careful of

  • Tell your doctor if you get vaginal itching or discharge, sore mouth or tongue.

This is due to a fungal infection called thrush. Sometimes use of this medicine allows fungi to grow, as CILICAINE SYRINGE 1.5 is ineffective against fungi.

  • If you get diarrhoea, nausea or vomiting, tell your doctor.

Do this even if it occurs several weeks after receiving your last CILICAINE SYRINGE 1.5 injection.

Driving or using machines

Be careful before you drive or use any machines or tools until you know how CILICAINE SYRINGE 1.5 affects you.

CILICAINE SYRINGE 1.5 generally does not affect your ability to drive a car or operate machinery. However, as with many other medicines, CILICAINE SYRINGE 1.5 may also cause dizziness, drowsiness and/or tiredness in some people.

Looking after your medicine

The syringes will be kept on the hospital ward or in the pharmacy.

Keep the syringes in the pack until it is time to take them.

Store CILICAINE SYRINGE 1.5 between 2 and 8 degrees Celsius.

6. Are there any side effects?

Tell your doctor or nurse as soon as possible if you do not feel well while you are taking CILICAINE SYRINGE 1.5.

All medicines can have side effects. If you do experience any side effects, most of them are minor and temporary. However, some side effects may need medical attention.

See the information below and, if you need to, ask your doctor or nurse if you have any further questions about side effects.

Do not be alarmed by the following lists of side effects. You may not experience any of them.

Side effects

Side effects What to do
  • diarrhoea
  • nausea & vomiting
  • skin rash
  • difficulty in breathing
Speak to your doctor if you have any of these side effects

Tell your doctor or nurse if you notice anything else that may be making you feel unwell.

Other side effects not listed here may occur in some people.

Reporting side effects

After you have received medical advice for any side effects you experience, you can report side effects to the Therapeutic Goods Administration online at By reporting side effects, you can help provide more information on the safety of this medicine.

Always make sure you speak to your doctor or pharmacist before you decide to stop taking any of your medicines.

7. Product details

This medicine is only available with a doctor’s prescription.

What CILICAINE SYRINGE 1.5 contains

Active ingredient
(main ingredient)
1.5 mg of procaine benzylpenicillin (procaine penicillin)
Other ingredients
(inactive ingredients)

polysorbate 80

sodium citrate

water for injections

Potential allergens None

CILICAINE SYRINGE 1.5 syringe injection is preservative free.

Do not take this medicine if you are allergic to any of these ingredients.

What CILICAINE SYRINGE 1.5 looks like

CILICAINE SYRINGE 1.5 is a slightly viscous white suspension with a faint odour characteristic of penicillin.

(AUST R 288818).


Viatris Pty Ltd
Level 1, 30 The Bond
30-34 Hickson Road
Millers Point NSW 2000
Phone: 1800 274 276

This leaflet was prepared in May 2022.

CILICAINE® is a Viatris company trade mark